The other serelaxin in acute heart failure study: lessons from a pragmatic clinical trial
نویسندگان
چکیده
منابع مشابه
Serelaxin, a 'breakthrough' investigational intravenous agent for acute heart failure.
Recombinant relaxin (serelaxin), a breakthrough therapy for acute heart failure.
متن کاملTherapeutic effects of serelaxin in acute heart failure.
Over the past few decades, research on the peptide hormone, relaxin, has significantly improved our understanding of its biological actions under physiological and diseased conditions. This has facilitated the conducting of clinical trials to explore the use of serelaxin (human recombinant relaxin). Acute heart failure (AHF) is a very difficult to treat clinical entity, with limited success so ...
متن کاملSerelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial
AIMS Serelaxin is effective in relieving dyspnoea and improving multiple outcomes in acute heart failure (AHF). Many AHF patients have preserved ejection fraction (HFpEF). Given the lack of evidence-based therapies in this population, we evaluated the effects of serelaxin according to EF in RELAX-AHF trial. METHODS AND RESULTS RELAX-AHF randomized 1161 AHF patients to 48-h serelaxin (30 μg/kg...
متن کاملHospital recruitment for a pragmatic cluster-randomized clinical trial: Lessons learned from the COMPASS study
BACKGROUND Pragmatic randomized clinical trials are essential to determine the effectiveness of interventions in "real-world" clinical practice. These trials frequently use a cluster-randomized methodology, with randomization at the site level. Despite policymakers' increased interest in supporting pragmatic randomized clinical trials, no studies to date have reported on the unique recruitment ...
متن کاملSerelaxin: insights into its haemodynamic, biochemical, and clinical effects in acute heart failure.
Adrian V. Hernandez, MD, PhD, FACC Postgraduate School, Universidad Peruana de Ciencias Aplicadas (UPC), Lima 27, Peru; and Health Outcomes and Clinical Epidemiology Section, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland,OH 44195, USA. Tel: +51-954157044; email: [email protected] Conflicts of interest: I declare I have no conflict...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Heart Failure
سال: 2019
ISSN: 1388-9842,1879-0844
DOI: 10.1002/ejhf.1416